9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One 9-溴-7,12-二氢苯并[2,3]氮杂卓并[4,5-b]吲哚-6(5H)-酮

CAS 142273-20-9 MFCD02683595

化学结构图

142273-20-9
SMILES: O=C1CC2=C(NC3C=CC(Br)=CC=32)C2C=CC=CC=2N1

化学属性

Mol. FormulaC16H11BrN2O
Mol. Weight327.18

别名和识别编码

Chemical Name9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One
CAS Number142273-20-9
Synonym 9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one 9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one NSC 664704 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one 9-Bromopaullone Kenpaullone NSC 664704
MDL NumberMFCD02683595
PubChem Substance ID253661159
Chemical Name Translation9-溴-7,12-二氢苯并[2,3]氮杂卓并[4,5-b]吲哚-6(5H)-酮
Reaxys-RN5346108
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分类

  • {SNA} Apopt
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin-Dependent Kinase (CDK), K, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学,
  • Inhibitors
  • {S

产品应用

  • The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3? inhibitor (IC50=23nM).

相关文献及参考

  • Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999),
  • Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001),

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition <0°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. K - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Cyclin-Dependent Kinase (CDK) - Serine/Threonine Kinase Inhibitors

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