CI-1040 2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺

CAS 212631-79-3 MFCD02683961

化学结构图

212631-79-3
SMILES: O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl

化学属性

Mol. FormulaC17H14ClF2IN2O2
Mol. Weight478.66
Melting Point176.0 to 180.0 deg-C
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameCI-1040
CAS Number212631-79-3
Synonym 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide CI-1040 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide 3,4-Difluoro-2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxybenzamide CI 1040 CI-1040 CI1040; CI-1040; CI 1040; PD184352; PD 184352; PD-184352.
MDL NumberMFCD02683961
PubChem Substance ID329823755
Chemical Name Translation2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺
Reaxys-RN10032343
FormulaC17H14ClF2IN2O2
IUPAC Name2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
InChIKeyGFMMXOIFOQCCGU-UHFFFAOYSA-N
InChIInChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
Canonical SMILESO=C(NOCC1CC1)C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3Cl
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase Kinase (MAPKK), P-PH, Pfizer Compounds, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Approved Therapeutics/Drug C

产品应用

  • CI-1040, also known as PD184352, is a MEK inhibitor, which demonstrated in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated.

相关文献及参考

  • Adeyinka, A., et al.: Clin. Cancer Res., 8, 1747 (2002),
  • Watanabe K., et al., Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin. Cancer Res. 16 , 1170-1178, (2010) 摘要
  • Kiyonari H., et al., Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. Genesis 48 , 317-327, (2010) 摘要
  • Mattingly R.R.,, The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines. J. Pharmacol. Exp. Ther. 316 , 456-465, (2006) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word Warning
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes N
Risk Statements
  • R50/53
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Mitogen-Activated Protein Kinase Kinase (MAPKK) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. Apoptosis
  3. PERK
  1. Medical Research Areas
  2. JAK/STAT
  3. ERK
  1. Medical Research Areas
  2. MARK
  3. MEK

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