N,N,2-Trimethyl-5-nitrobenzenesulfonamide 2-甲基-5-硝基-N,N-二甲基苯磺酰胺
CAS 433695-36-4 MFCD03039912
化学结构图
SMILES: CC1=CC=C(C=C1S(=O)(=O)N(C)C)[N+]([O-])=O
化学属性
| Mol. Formula | C9H12N2O4S |
|---|---|
| Mol. Weight | 244.27 |
| Melting Point | 71.0 to 75.0 deg-C |
别名和识别编码
| Chemical Name | N,N,2-Trimethyl-5-nitrobenzenesulfonamide |
|---|---|
| CAS Number | 433695-36-4 |
| Synonym | 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene, 5-Nitro-2-N,N-trimethylbenzenesulfonamide 5-Nitro-2,N,N-trimethylbenzenesulfonamide BRL 50481 |
| MDL Number | MFCD03039912 |
| PubChem Substance ID | 253662021 |
| Chemical Name Translation | 2-甲基-5-硝基-N,N-二甲基苯磺酰胺 |
| Reaxys-RN | 9999290 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, GlaxoSmithKline, P to Q, Phosphodiesterase 7, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
- Inhibitors
- {SNA} Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, GlaxoSmithKline, P to Q, Phosphodiesterase 7
产品应用
- A PDE7 inhibitor that has acceptable selectivity for in vivo studies.
相关文献及参考
- [2]. Smith SJ, et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol. 2004 Dec;66(6):1679-89.
- Smith, S.J., et al., Discovery of BRL 50481, a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages and CD8 + T-lymphocytes. Mol. Pharmacol. 66 , 1679-1689 , (2004)
- Smith, S.J., et al.: Mol. Pharmacol., 66, 1679 (2004)
- [1]. Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun;8(6):733-51.
- [1]. Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun;8(6):733-51.
- [2]. Smith SJ, et al. Discovery of BRL 50481
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