Nobiletin 2-(3,4-二甲氧基苯基)-5,6,7,8-四甲氧基-4H-苯并吡喃-4-酮

CAS 478-01-3 MFCD03273560

化学结构图

478-01-3
SMILES: COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC

化学属性

Mol. FormulaC21 H22 O8
Mol. Weight402.39
Density1.422
Melting Point136-140
Solubility微溶于水和乙醚。,

别名和识别编码

Chemical NameNobiletin
CAS Number478-01-3
Synonym 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 3', 4', 5, 6, 7, 8-Hexamethoxyflavone 3',4',5,6,7,8-HEXAMETHOXYFLAVONE 3',4',5,6,7,8-Hexamethoxyflavone 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)- 5,6,7,8-tetramethoxy- Flavone, 5,6,7,8,3',4'-hexamethoxy NOBILETIN NOBILETIN WITH HPLC NOBILETIN, 20% (TECHNICAL GRADE) Nobiletin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chembl {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalb {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD03273560
EC Number250-023-7
Beilstein Registry Number18(5)5,667
Reaxys-RN360887
PubChem Substance ID125307388
Chemical Name Translation2-(3,4-二甲氧基苯基)-5,6,7,8-四甲氧基-4H-苯并吡喃-4-酮
LabNetwork Molecule IDLN00382354
InChIInChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
Canonical SMILESO=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
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分类

  • {SNA} Cell Biology, Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Flavanols, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Flavanols, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {SNA} Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Flavanols, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)

相关文献及参考

  • [2]. Nohara K, et al. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. Nat Commun. 2019 Aug 28;10(1):3923.
  • [3]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Jul;94(7):728-33.
  • [4]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.
  • [1]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Jun 7;7(23):35208-23.
  • [1]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Jun 7;7(23):35208-23.
  • [2]. Nohara K, et al. Nobiletin fortifies mitochondrial respiration in

安全信息

WGK Germany3
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSDJ3052200
Storage condition +4°C 2-8°C 4℃ <0°C <;0 储存温度 -20°C

其他信息

  • 蜜橘黄素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0871 川皮苷 Nobiletin 10MG 2390元 2014/06/02 N0871 川皮苷 Nobiletin 100MG 10950元
  • MOL 文件:478-01-3.mol

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Citrus aurantium (Seville orange) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. ROR  (维甲酸相关孤儿受体)

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