(Z)-Isopropyl 7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R,E)-3-Hydroxy-4-(3-(Trifluoromethyl)Phenoxy)But-1-En-1-Yl)Cyclopentyl)Hept-5-Enoate (Z)-异丙基-7-((1R,2R,3R,5S)-3,5-二羟基-2-((R,E)-3-羟基-4-(3-(三氟甲基)苯氧基)丁-1-烯-1-基)环戊基)庚-5-烯酸酯
CAS 157283-68-6 MFCD03411995
化学结构图
SMILES: CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1
化学属性
| Mol. Formula | C26H35F3O6 |
|---|---|
| Mol. Weight | 500.55 |
别名和识别编码
| Chemical Name | (Z)-Isopropyl 7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R,E)-3-Hydroxy-4-(3-(Trifluoromethyl)Phenoxy)But-1-En-1-Yl)Cyclopentyl)Hept-5-Enoate |
|---|---|
| CAS Number | 157283-68-6 |
| Synonym | (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2 (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2 Travoprost (5Z)- Fluprostenol isopropyl ester Travoprost |
| MDL Number | MFCD03411995 |
| EC Number | 200-578-6 |
| PubChem Substance ID | 329799691 |
| Chemical Name Translation | (Z)-异丙基-7-((1R,2R,3R,5S)-3,5-二羟基-2-((R,E)-3-羟基-4-(3-(三氟甲基)苯氧基)丁-1-烯-1-基)环戊基)庚-5-烯酸酯 |
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分类
- Pharmaceuticals
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F, Lipids in Cell Signaling, Prostaglandins
- Chiral Reagents
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, F, Lipids in Cell Signaling, Prostaglandins,
产品应用
- Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma.
相关文献及参考
- Hellberg, M.R., et al.: J. Ocul. Pharmacol. Ther., 17, 421 (2001),
- McCue, B.A., et al.: J. Pharm. Biomed. Anal., 28, 199 (2002),
- Schuman, J.S., et al.: Am. J. Ophthalmol., 140, 242 (2005),
- [1]. M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17(5):421-32.
安全信息
- S7 Keep container tightly closed 保存在严格密闭容器中；
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R11 Highly flammable 非常易燃
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P337+P313
- P403+P235
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
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