N-(4-(1,1,1,3,3,3-Hexafluoro-2-Hydroxypropan-2-yl)Phenyl)-N-(2,2,2-Trifluoroethyl)Benzenesulfonamide N-(4-(1,1,1,3,3,3-六氟-2-羟基丙-2-基)苯基)-N-(2,2,2-三氟乙基)苯磺酰胺
CAS 293754-55-9 MFCD03412028
化学结构图
SMILES: O=S(=O)(c1ccccc1)N(CC(F)(F)F)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
化学属性
| Mol. Formula | C17H12NSO3F9 |
|---|---|
| Mol. Weight | 481.33 |
别名和识别编码
| Chemical Name | N-(4-(1,1,1,3,3,3-Hexafluoro-2-Hydroxypropan-2-yl)Phenyl)-N-(2,2,2-Trifluoroethyl)Benzenesulfonamide |
|---|---|
| MDL Number | MFCD03412028 |
| PubChem Substance ID | 447912 |
| Synonym | N-(2,2,2-Trifluoroethyl)-N-(4-(2,2,2-trifluoro-1- hydroxy-1-trifluoromethylethyl)phenyl)benzenesulfonamide N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide T 0901317 T 1371 T-0901317 T-1371 T0901317 T1371 cpd TO-901317 TO901317 |
| CAS Number | 293754-55-9 |
| Chemical Name Translation | N-(4-(1,1,1,3,3,3-六氟-2-羟基丙-2-基)苯基)-N-(2,2,2-三氟乙基)苯磺酰胺 |
| LabNetwork Molecule ID | LN01310312 |
| InChI | InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators, T
- {SNA} Gene Regulation and Expression, PPAR and RXR Regulators, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Keith A Houck, et al. T0901317 Is a Dual LXR/FXR Agonist. Mol Genet Metab. Sep-Oct 2004;83(1-2):184-7.
- [3]. Naresh Kumar, et al. The Benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-Alpha/Gamma Inverse Agonist. Mol Pharmacol. 2010 Feb;77(2):228-36.
- [4]. Rough JJ, et al. Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res. 2010 May 26;3:13.
- [5]. Todd G Kirchgessner, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33.
- [6]. Mingming Gao, et al. The Liver X Receptor Agonist T0901317 Protects Mice From High Fat Diet-Induced Obesity and Insulin Resistance. AAPS J. 2013 Jan;15(1):258-66.
- [1]. J R Schultz, et al. Role of LXRs in Control of
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