Quetiapine hemifumarate salt 喹硫平半富马酸盐

CAS 111974-72-2 MFCD03423782

化学结构图

111974-72-2
SMILES: OC(=O)/C=C/C(O)=O.OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C21.OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C21

化学属性

Mol. FormulaC46H54N6O8S2
Mol. Weight883
Melting Point172-176

别名和识别编码

Chemical NameQuetiapine hemifumarate salt
Synonym 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate Quetiapine fumarate Quetiapine Fumarate Quetiapine hemifumarate salt
MDL NumberMFCD03423782
Beilstein Registry Number8378094
Chemical Name Translation喹硫平半富马酸盐
Reaxys-RN8378094
Merck Number8039
PubChem Substance ID160871365
CAS Number111974-72-2
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分类

  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Serotonergics
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
  • {SNA} Antagon

相关文献及参考

  • [2]. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
  • [1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
  • [1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
  • [2]. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.

安全信息

Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312+P330
  • P308+P311
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
Signal word Danger
Hazard Codes 9
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
UN Number 3077
RTECSKK3605000
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Dopaminergics - Neurotransmitters
  8. Antagonists - Dopaminergics
  1. Functional Group 官能团索引
  2. carboxylic acid amidine
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  4. 5-HT Receptor  (5-羟色胺受体)
  5. 5-HT Receptor  (5-羟色胺受体)
  6. 5-HT Receptor  (5-羟色胺受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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