3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one 3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮

CAS 220904-83-6 MFCD03453076

化学结构图

220904-83-6
SMILES: O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1

化学属性

Mol. FormulaC15H8Br2INO2
Mol. Weight520.94
Appearance solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
Synonym 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one GW5074 GW5074; GW 5074; GW-5074;
MDL NumberMFCD03453076
PubChem Substance ID24278455
CAS Number220904-83-6
Chemical Name Translation3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮
FormulaC15H8Br2INO2
IUPAC Name3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
InChIKeyLMXYVLFTZRPNRV-KMKOMSMNSA-N
InChIInChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
Canonical SMILESO=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G, Kinase/Phosphatase Biology,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G, Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein Kinase, cRAF1, Raf, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

产品应用

  • GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have therapeutic value against neurodegenerative pathologies in humans.

相关文献及参考

  • Lackey, K., et al, The discovery of potent cRaf1 kinase inhibitors. Bioorg. Med. Chem. Lett. 10 , 223, (2000) 摘要
  • Zhang Q, Adiseshaiah P, Kalvakolanu DV, Reddy SP, A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. J. Biol. Chem. , 10174-81, (2006) 摘要
  • Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR, Neuroprotection by histone deacetylase-related protein. Mol. Cell. Biol. , 3550-64, (2006) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Protein Kinase, cRAF1 - P to Q
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Raf - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. JAK/STAT
  3. ERK
  1. Medical Research Areas
  2. MARK
  3. MEK
  1. Medical Research Areas
  2. MARK
  3. Raf

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