Tdzd-8 4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

CAS 327036-89-5 MFCD04973552

化学结构图

327036-89-5
SMILES: CN1SC(=O)N(CC2C=CC=CC=2)C1=O

化学属性

Mol. FormulaC10H10N2O2S
Mol. Weight222
Melting Point61.0 to 65.0 deg-C

别名和识别编码

Chemical NameTdzd-8
CAS Number327036-89-5
Synonym 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione GSK-3? Inhibitor I, TDZD-8
MDL NumberMFCD04973552
PubChem Substance ID354334062
Chemical Name Translation4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
Reaxys-RN8763878
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glycogen Synthase Kinase 3 (GSK3),
  • {SNA} Bioactive Small Molecule Alphabetical Index,
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glycogen Synthase Kinase 3 (GSK3), Glycogen synthase kinase, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T
  • {SNA} Bioactive Small M

产品应用

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相关文献及参考

  • Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)
  • Martinez et al., First non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J. Med. Chem. 45 , 1292-1299, (2002)
  • Chen, G. et al., Glycogen synthase kinase 3ß (GSK3ß) mediates 6-hydroxydopamine-induced neuronal.death.. FASEB J. 18 , 1162-1164., (2004) 摘要

安全信息

GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P333+P313+P362+P364
  • P342+P311
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Hazard Codes Xi
WGK Germany3
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition -20°C

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Glycogen synthase kinase - D to K
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Glycogen Synthase Kinase 3 (GSK3) - Serine/Threonine Kinase Inhibitors

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