Zebularine 泽布拉林

CAS 3690-10-6 MFCD04973699

化学结构图

3690-10-6
SMILES: O=c1ncccn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

化学属性

Mol. FormulaC9H12N2O5
Mol. Weight228.20

别名和识别编码

Chemical NameZebularine
CAS Number3690-10-6
Synonym 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one 2-Pyrimidone-1-β-D-riboside 1-?-D-Ribofuranosyl- 2-Pyrimidone-1-β-D-riboside Zebularine
MDL NumberMFCD04973699
Chemical Name Translation泽布拉林
Reaxys-RN751056
PubChem Substance ID100016
InChIInChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1
LabNetwork Molecule IDLN01326575
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分类

  • {SNA} A to C, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cytidine deaminase, DNA Methyltransferase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, E
  • Inhibitors
  • Carbohydrates & Derivatives
  • Pharmaceuticals
  • {SNA} A to C, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cytidine deaminase, DNA Methyltransferase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Nucleoside analog inhibitors, Z, 分子生物学, 生物活性小分子, 细胞生物学,

产品应用

  • It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

相关文献及参考

  • Driscoll, J., et al.: J. Med. Chem., 34, 3280
  • Cheng, J.C., et al., Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J. Natl. Cancer Inst. 95 , 399-409, (2003) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSUW7539720
Storage condition 0-10 0-10°C 储存温度2-8°C

系列性分类


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