N,N-Dimethyl-N-(4-(2-(P-Tolyl)-6,7-Dihydro-5H-Benzo[7]Annulene-8-Carboxamido)Benzyl)Tetrahydro-2H-Pyran-4-Aminium Chloride N,N-二甲基-N-(4-(2-(对甲苯基)-6,7-二氢-5H-苯并[7]环庚烯-8-甲酰胺基)苄基)四氢-2H-吡喃-4-铵氯化物

CAS 229005-80-5 MFCD05662319

化学结构图

229005-80-5
SMILES: [Cl-].CC1C=CC(=CC=1)C1=CC2C=C(CCCC=2C=C1)C(=O)NC1C=CC(C[N+](C)(C)C2CCOCC2)=CC=1

化学属性

Mol. FormulaC33H39N2O2.Cl
Mol. Weight531.136

别名和识别编码

Chemical NameN,N-Dimethyl-N-(4-(2-(P-Tolyl)-6,7-Dihydro-5H-Benzo[7]Annulene-8-Carboxamido)Benzyl)Tetrahydro-2H-Pyran-4-Aminium Chloride
Chemical Name TranslationN,N-二甲基-N-(4-(2-(对甲苯基)-6,7-二氢-5H-苯并[7]环庚烯-8-甲酰胺基)苄基)四氢-2H-吡喃-4-铵氯化物
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相关文献及参考

  • [2]. Takama Y, et al. Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model. Transpl Immunol. 2011 Jul;25(1):49-55.
  • [3]. Ni J, et al. The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function. Br J Pharmacol. 2009 Dec;158(8):2046-56.
  • [4]. Gao P, et al. The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol. 2003 Feb;73(2):273-80.
  • [1]. Baba M, et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl
  • [1]. Baba M, et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. CCR  (趋化因子受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. CXCR  (CXC趋化因子受体)

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