Canrenoic Acid Potassium Salt 坎利酸钾盐

CAS 2181-04-6 MFCD05662375

化学结构图

2181-04-6
SMILES: CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC2(O)CCC(=O)[O-].[K+]

化学属性

Mol. FormulaC22H29KO4
Mol. Weight396.57 g/mol
Appearance powder 微黄白色到黄褐色结晶性粉末。

别名和识别编码

Chemical NameCanrenoic Acid Potassium Salt
CAS Number2181-04-6
Synonym ######## 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID POTASSIUM SALT 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid potassium salt 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid Potassium canrenoate 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid potassium salt; Canrenoic acid potassium salt 17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt (8CI) 17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, potassium salt (7CI) 4,6-ANDROSTADIEN-17ALPHA-YL-PROPIONIC ACID-17BETA-OL-3-ONE POTASSIUM SALT Aldadiene-kalium Aldadiene-potassium CANRENOIC ACID POTASSIUM SALT CB 8109 Canrenoa Canrenoate Canrenoate (potassium)
MDL NumberMFCD05662375
PubChem Substance ID23671691
EC Number218-554-9
Chemical Name Translation坎利酸钾盐
Wiswesser Line NotationL E5 B666 OV KU MUTJ A1 E1 FQ F2VQ &-KA-
LabNetwork Molecule IDLN02126534
InChIInChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1
Canonical SMILESC[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
  • {SNA} Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones,

产品应用

  • Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.

相关文献及参考

  • Brambilla, G., and Martelli, A., Are some progestins genotoxic liver carcinogens?. Mutat. Res. 512 , 155-163, (2002)
  • Los, L., et al.: Drug Metab. Dispos., 21, 1086 (1993),
  • Martelli, A., et al., Genotoxicity testing of potassium canrenoate in cultured rat and human cells. Mutagenesis 14 , 463-472, (1999) 摘要
  • Merck 14 ,1750
  • Peterfalvi, M., et al.: Biochem. Pharmacol., 29, 353 (1980),
  • Sadee, W., et al.: J. Pharm. Sci., 61, 1126 (1972),
  • Young, M., and Funder, J., Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology 144 , 3848-3851, (2003)
  • [1]. Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922.

安全信息

RTECSTU3500000
GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 11,811,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,8,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 11,811,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperiton

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,196,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 150 mg/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   61,201,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 560 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 36,261,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 420 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 36,261,1977

Storage condition 2-8°C Store at room temperature

其他信息

  • Sigma Aldrich:2181-04-6(sigmaaldrich)
  • MOL 文件:2181-04-6.mol
  • color:light yellow to tan

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Mineralocorticoid Receptor  (盐皮质激素受体)

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