6-(Cyclohexylmethoxy)-9H-Purin-2-Amine 6-(环己基甲氧基)-9H-嘌呤-2-胺

CAS 161058-83-9 MFCD05664734

化学结构图

161058-83-9
SMILES: Nc1nc(OCC2CCCCC2)c2nc[nH]c2n1

化学属性

Mol. FormulaC12H17N5O
Mol. Weight247.3
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name6-(Cyclohexylmethoxy)-9H-Purin-2-Amine
Synonym NU2058; NU 2058; NU-2058. O6-Cyclohexylmethylguanine
MDL NumberMFCD05664734
PubChem Substance ID253661766
CAS Number161058-83-9
Chemical Name Translation6-(环己基甲氧基)-9H-嘌呤-2-胺
Reaxys-RN7645499
FormulaC12H17N5O
IUPAC Name6-(cyclohexylmethoxy)-9H-purin-2-amine
InChIKeyMWGXGTJJAOZBNW-UHFFFAOYSA-N
InChIInChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17)
Canonical SMILESNC1=NC(OCC2CCCCC2)=C3N=CNC3=N1
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分类

  • {SNA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin Dependant Kinase 2, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, N, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Cycle Proteins and Antibodies,

产品应用

  • NU2058 is a potent CDK inhibitor that has CDK2 IC(50)=17 microM and CDK1 IC(50)=26 microM.

相关文献及参考

  • Gibson, A. E., et al, Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J. Med. Chem. 45 , 3381-3393 , (2002)
  • Knockaert, M., et al, Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol. Sci. 23 , 417-425, (2002)

安全信息

GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 0-10°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Cyclin Dependant Kinase 2 - A to C
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Medical Research Areas
  2. Cell Cycle
  3. CDK

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