Ascomycin 长川霉素

CAS 104987-12-4 MFCD06198665

化学结构图

104987-12-4
SMILES: CC[C@@H]1C=C(C)C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)/C(/C)=C/[C@H]1C[C@@H](OC)[C@H](O)CC1 |c:3|

化学属性

Mol. FormulaC43H69NO12
Mol. Weight792
Melting Point160-161

别名和识别编码

Chemical NameAscomycin
CAS Number104987-12-4
Synonym FR 900520 FR 520 Ascomycin L 683590 Immunomycin FK 520 Changchuanmycin
MDL NumberMFCD06198665
PubChem Substance ID24890817
Beilstein Registry Number5372600
Chemical Name Translation长川霉素
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分类

  • {SNA}
  • {SNA} AN-AZ, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecule Alphabetical Index, Chemical Structure Class, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Kinase/Phosphatase Biology, Macrolactams, Protein Phosphatase 2B (Calcineurin/PP2B), Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Inhibitors, Spectrum of Activity, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • AN-AZ, Antibiotics, Antibiotics A to Z,

产品应用

  • A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.

相关文献及参考

  • Matuszewski, B., et al.: Anal. Chem., 75, 3019 (2003),
  • Taylor, P., et al.: Clin. Chem., 51, 1890(2005),
  • Kawai, M., et al. FEBS Lett. 316 , 107, (1993) 摘要
  • Mollison, K.W., et al. Ann. N.Y. Acad. Sci. 685 , 55, (1993) 摘要

安全信息

RTECSKD4185000
WGK Germany3
GHS Symbol
Precautionary statements
Signal word
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1592,1988

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. Immunomodulators and Antibiotics - Immune System Regulation
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Phosphatase Inhibitors - Serine/Threonine Kinase Biology
  7. Protein Phosphatase 2B (Calcineurin/PP2B) - Serine/Threonine Phosphatase Inhibitors

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