20(S)-Ginsenoside Rg3 人参皂甙Rg3

CAS 14197-60-5 MFCD06410950

化学结构图

14197-60-5
SMILES: CC1(C)[C@@H]2CC[C@]3(C)[C@H](C[C@@H](O)[C@@H]4[C@H](CC[C@@]34C)[C@@](C)(O)CCC=C(C)C)[C@@]2(C)CC[C@@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

化学属性

Mol. FormulaC42H72O13
Mol. Weight785
Melting Point209-219
Density1.30

别名和识别编码

Chemical Name20(S)-Ginsenoside Rg3
Synonym (20S)-Propanaxadiol
CAS Number14197-60-5
MDL NumberN/A
Chemical Name Translation人参皂甙Rg3
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分类

  • {SNA} Alphabetical, Analytical Standards, Analytical/Chromatography, Chromatography, E - H, Isoprenoids, Life Sciences Standards, Nutrition Research, Panax, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Phytopharma Standards, Standards by Plant Genus, Substance Classification
  • {SNA} Bioactive Small Molecule Alphabetical Index, G, Ion Channels, Monovalent Ion Channels, Phytochemicals by Chemical Classification, Potassium Channel Modulators, Saponins, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,

相关文献及参考

  • [2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26.
  • [3]. Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601.
  • [4]. Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.
  • [1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na + channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42.
  • [1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na + channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42.
  • [2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;7

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Signal word Warning
RTECSLY9537300
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,343,1975

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P330 Rinse mouth. 漱口

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. G - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. E - H - Alphabetical
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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