Asiaticoside 积雪草苷

CAS 16830-15-2 MFCD06642601

化学结构图

16830-15-2
SMILES: C[C@@]12CC[C@]3(CC[C@@H](C)[C@H](C)[C@@H]3C1=CC[C@H]1[C@@]2(C)CC[C@H]2[C@](C)(CO)[C@@H](O)[C@H](O)C[C@@]21C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O

化学属性

Mol. FormulaC48H78O19
Mol. Weight959
Melting Point230-233

别名和识别编码

Chemical NameAsiaticoside
Synonym Madecassol Madecassol, 2alpha,3beta,23-Trihydroxy-urs-12-en-28-saeure(O-alpha-L-rhamnopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl)ester 积雪草甙
MDL NumberMFCD06642601
PubChem Substance ID24867054
CAS Number16830-15-2
EC Number240-851-7
Beilstein Registry Number78195
Chemical Name Translation积雪草苷
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分类

  • A, A - D, AR to AZ, Alcohols, Alphabetic, Alphabetical, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Esters, Heterocyclics, Isoprenoids, Life Sciences Standards, Natural Compounds, Natural Terpene Standards, Other, Oxygen containing, Phytopharma Standards, Polyhydroxy compounds, Punica, Standards by Plant Genus, Substance Classification
  • {SNA} A, A - D, AR to AZ, Alcohols,

相关文献及参考

  • [2]. Wang X, et al. Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension. Mol Med Rep. 2018 Feb;17(2):2893-2900.
  • [3]. Zhang Z, et al. Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors. Exp Ther Med. 2017 Feb;13(2):413-420.
  • Merck 14 ,833
  • [1]. Tang B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. h Dermatol Res. 2011 Oct;303(8):563-72.
  • [1]. Tang B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. h Dermatol Res. 2011 Oct;303(8):563-72.
  • [2]. Wang X, et al. Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension. Mol Med Rep. 2018 Feb;17(2):2893-2900.
  • [3

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,1463,1972

RTECSYU9625000
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Natural Compounds - Chemical Class
  5. Natural Terpene Standards - Natural Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AR to AZ - A
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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