Calyculin A from Discodermia calyx
CAS 101932-71-2 MFCD06795864
化学结构图
SMILES: CC1(C)[C@@H](OP(O)(O)=O)[C@H](O[C@@]21C[C@@H](O)[C@H](C)[C@H](C/C=C/C1=COC(=N1)[C@@H](C)CCNC(=O)[C@@H](O)[C@@H](O)[C@H](COC)N(C)C)O2)[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(\C)/C(/C)=C/C=C/C(/C)=C\C#N)OC
化学属性
| Mol. Formula | C50H81N4O15P |
|---|---|
| Mol. Weight | 1009.17 |
别名和识别编码
| Chemical Name | Calyculin A from Discodermia calyx |
|---|---|
| CAS Number | 101932-71-2 |
| PubChem Substance ID | 329752128 |
| Beilstein Registry Number | 4903216 |
| MDL Number | MFCD06795864 |
| Synonym | Calyculin A from Discodermia calyx |
| Chemical Name Translation |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index,
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Substrates, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Substrates,
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, P to Q, Phosphatase Inhibitors, Protein Phosphatase 1 (PP1), Protein phosphatase-1, Catalytic Subunit, Serine/Threonine Kinase Biology,
相关文献及参考
- [2]. Hiroaki Tanaka,et al. Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. Int J Oncol. 2007 Aug;31(2):389-96.
- Bize, et al., Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes. Am. J. Physiol. 277 , C926-C936, (1999) 摘要
- Condrescu, et al., Mode-specific inhibition of sodium-calcium exchange during protein phosphatase blockade. J. Biol. Chem. 274 , 33279-33286, (1999) 摘要
- Debnath, J., Detachment-induced Autophagy In Three-dimensional Epithelial Cell Cultures. Meth. Enzymol. 452 , 423-39, (2009) 摘要
- Fujiki, H., and Suganuma, M., Unique features of the okadaic acid activity class of tumor promoters. J. Cancer Res. Clin. Oncol. 125 , 150-155, (1999) 摘要
- Iizuka, et al., A major role for the Rho-associated coiled coil forming protein kinase in G-protein-mediated Ca 2+ sensitization through inhibition of myosin phosphatase
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H331 Toxic if inhaled 吸入中毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H301 Toxic if swallowed 吞食有毒
- H301+H311+H331
- P301+P310
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R38 Irritating to skin 刺激皮肤
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
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