Palonosetron Hydrochloride (S)-2-((S)-奎宁环-3-基)-2,3,3a,4,5,6-六氢-1H-苯并[de]异喹啉-1-酮盐酸盐
CAS 135729-62-3 MFCD07370072
化学结构图
SMILES: Cl.O=C1C2C=CC=C3CCC[C@H](CN1[C@@H]1CN4CCC1CC4)C3=2
化学属性
| Mol. Formula | C19H24N2O·HCl |
|---|---|
| Mol. Weight | 333 |
别名和识别编码
| Chemical Name | Palonosetron Hydrochloride |
|---|---|
| CAS Number | 135729-62-3 |
| Synonym | (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride Aloxi Onicit Palonosetron HCl |
| Chemical Name Translation | (S)-2-((S)-奎宁环-3-基)-2,3,3a,4,5,6-六氢-1H-苯并[de]异喹啉-1-酮盐酸盐 |
| Reaxys-RN | 21177207 |
| MDL Number | MFCD07370072 |
| PubChem Substance ID | 253660260 |
| Merck Number | 6997 |
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分类
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
相关文献及参考
- [2]. Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H.
- [3]. Ruhlmann C, Herrstedt J.
- [4]. Trissel LA, Trusley C, Ben M, Kupiec TC.
- [5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.J. Med. Chem., 1993, 36 (18), pp 2645-2657
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- Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.
- Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.
- Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds
- Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase.
安全信息
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