SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively). SU5402

CAS 215543-92-3 MFCD08235144

化学结构图

215543-92-3
SMILES: Cc1c[nH]c(/C=C2\C(=O)Nc3ccccc32)c1CCC(=O)O

化学属性

Mol. FormulaC17H16N2O3
Mol. Weight296.32054
Appearance Orange solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameSU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).
CAS Number215543-92-3
Synonym 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl- 3-((3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene)-2-inolinone 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid PF-02969207 PNU-0290908 PF-02969207 PNU-0290908 SU 5402 SU-5402 SU5402 SU5402; SU-5402; SU 5402. Su-5402
MDL NumberMFCD08235144
PubChem Substance ID5289418
Chemical Name TranslationSU5402
InChIInChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
FormulaC17H16N2O3
IUPAC Name(Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid.
InChIKeyJNDVEAXZWJIOKB-JYRVWZFOSA-N
Canonical SMILESO=C(O)CCC1=C(/C=C2C(NC3=C\2C=CC=C3)=O)NC=C1C
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, FGF Receptors, Fibroblast Growth Factor Receptor (FGFR), Fibroblast Growth Factors (FGF), Kinase/Phosphatase Biology, New Products,
  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines and Growth Factors,

产品应用

  • SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).

相关文献及参考

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安全信息

WGK Germany3
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Cytokines and Growth Factors - Cytokines, Growth Factors and Hormones
  6. Fibroblast Growth Factors (FGF) - Cytokines and Growth Factors
  7. FGF Receptors - Fibroblast Growth Factors (FGF)
  1. Medical Research Areas
  2. Angiogenesis
  3. PDGFR

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