6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione 6-氯-7-((2吗啉乙基)氨基)喹啉-5,8-二酮
CAS 383907-43-5 MFCD08276924
化学结构图
SMILES: O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21
化学属性
| Mol. Formula | C15H16ClN3O3 |
|---|---|
| Mol. Weight | 321.76 |
别名和识别编码
| Chemical Name | 6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione |
|---|---|
| Synonym | 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione NSC 663284 NSC-663284 NSC663284 |
| CAS Number | 383907-43-5 |
| PubChem Substance ID | 379077 |
| MDL Number | MFCD08276924 |
| Chemical Name Translation | 6-氯-7-((2吗啉乙基)氨基)喹啉-5,8-二酮 |
| LabNetwork Molecule ID | LN01323753 |
| InChI | InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Cdc25 dual specificity phosphatase (Cdc25), Kinase/Phosphatase Biology, N, Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Bioactive Small Molecules, Cdc25 dual specificity phosphatase (Cdc25), Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, N, Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Inhibitors
相关文献及参考
- [2]. Coussens NP, et al. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2. J Biol Chem. 2018 Aug 31;293(35):13750-13765.
- [3]. Guo J, et al. Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). Anticancer Res. 2007 Sep-Oct;27(5A):3067-73.
- Han, Y., et al. J. Pharmacol. Exp. Ther. 309 , 64-70, (2004)
- [1]. Lazo JS, et al. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem. 2001 Nov 22;44(24):4042-9.
- [1]. Lazo JS, et al. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem. 2001 Nov 22;44(24):4042-9.
- [2]. Coussens NP, et al. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone l
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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