2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one 2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮

CAS 587871-26-9 MFCD08276985

化学结构图

587871-26-9
SMILES: O=c1cc(-c2cccc3c2Sc2ccccc2S3)oc(N2CCOCC2)c1

化学属性

Mol. FormulaC21H17NO3S2
Mol. Weight395
Appearance White to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one
Chemical Name Translation2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮
FormulaC21H17NO3S2
Synonym KU 55933; KU55933; KU-55933.
IUPAC Name2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
InChIKeyXRKYMMUGXMWDAO-UHFFFAOYSA-N
InChIInChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
Canonical SMILESO=C1C=C(N2CCOCC2)OC(C3=C4SC5=C(C=CC=C5)SC4=CC=C3)=C1
MDL Number
CAS Number587871-26-9
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产品应用

  • KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. For detail see: htt

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类


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