(-)-Blebbistatin 细胞抑制剂(-)-BLEBBISTATIN

CAS 856925-71-8 MFCD08460907

化学结构图

856925-71-8
SMILES: CC1C=C2C(=O)[C@]3(O)CCN(C3=NC2=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC18H16N2O2
Mol. Weight292.33

别名和识别编码

Chemical Name(-)-Blebbistatin
CAS Number856925-71-8
Synonym (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one (-)-Blebbistatin (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one
MDL NumberMFCD08460907
PubChem Substance ID329773119
Chemical Name Translation细胞抑制剂(-)-BLEBBISTATIN
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Actin Inhibitors and Probes, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cytoskeleton and Extracellular Matrix, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Inhibitors
  • Chiral Reagents
  • Pharmaceuticals
  • {SNA} Actin Inhibitors and Probes, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix
  • Intermediates & Fine Chemicals,

产品应用

  • ########

相关文献及参考

  • [2]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27.
  • Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004),
  • Straight, A.F., et al.: Science, 299, 1743 (2003),
  • [1]. Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin.
  • [1]. Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin.
  • [2]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27.

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Actin Inhibitors and Probes - Cytoskeleton and Extracellular Matrix
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Myosin  (肌球蛋白)

相关产品推荐