N,N-Dimethyl-5-[(4-Phenylphenyl)Methyl]Tetrazole-1-Carboxamide 5-([1,1’-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺

CAS 874902-19-9 MFCD08703123

化学结构图

874902-19-9
SMILES: CN(C)C(=O)N1N=NN=C1CC1C=CC(=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC17H17N5O
Mol. Weight307.35

别名和识别编码

Chemical NameN,N-Dimethyl-5-[(4-Phenylphenyl)Methyl]Tetrazole-1-Carboxamide
Synonym 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl- 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide 1H-Tetrazole-1-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl- 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide LY2183240
MDL NumberMFCD08703123
Chemical Name Translation5-([1,1’-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Eli Lilly, Neurobiology, Neuroscience, Pharmacologicals

相关文献及参考

  • [2]. Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.
  • [3]. Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc. 2006 Aug 2;128(30):9699-704.
  • [4]. Maione S, et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008 Nov;155(5):775-82.
  • [5]. Pelorosso FG, et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. Eur J Pharmacol. 2009 Jan 5;602(1):176-9.
  • [6]. Powers MS, et al. Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Eli Lilly - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. Metabolism
  3. FAAH  (脂肪酰胺水解酶)

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