1-(Tert-Butyl)-3-(2-((4-(DiethylAmino)Butyl)Amino)-6-(3,5-Dimethoxyphenyl)Pyrido[2,3-d]Pyrimidin-7-yl)Urea N-[2-[4-(二乙氨基)丁基]氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-D-7-嘧啶基]-N’-(1,1-二甲基)脲

CAS 219580-11-7 MFCD08705327

化学结构图

219580-11-7
SMILES: CC(C)(C)NC(=O)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C1C=C(C=C(C=1)OC)OC

化学属性

Mol. FormulaC28H41N7O3
Mol. Weight523.68

别名和识别编码

Chemical Name1-(Tert-Butyl)-3-(2-((4-(DiethylAmino)Butyl)Amino)-6-(3,5-Dimethoxyphenyl)Pyrido[2,3-d]Pyrimidin-7-yl)Urea
CAS Number219580-11-7
Synonym N-[2-[[4-(Diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea N-[2-[[4-(Diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
MDL NumberMFCD08705327
PubChem Substance ID354335228
Chemical Name TranslationN-[2-[4-(二乙氨基)丁基]氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-D-7-嘧啶基]-N’-(1,1-二甲基)脲
Reaxys-RN10130688
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology, FGF Receptors, Fibroblast Growth Factor Receptor (FGFR), Fibroblast Growth Factors (FGF), General Stem Cell Biology, Inhibitors, Kinase/Phosphatase Biology, P-PH,

产品应用

  • PD 173074

相关文献及参考

  • Mohammadi, M., et al.: Science, 276, 955 (1997),
  • Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A, FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development , 2895-902, (2006)
  • Cole, C.L., et al., Synthetic Heparan Sulfate Oligosaccharides Inhibit Endothelial Cell Functions Essential For Angiogenesis. PLoS ONE 5 , e11644, (2010) 摘要
  • Trudel, S., et al., Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 103 , 3521-3528, (2004)

安全信息

GHS Symbol
Precautionary statements
  • P302+P352+P332+P313+P362+P364
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Cytokines and Growth Factors - Cytokines, Growth Factors and Hormones
  6. Fibroblast Growth Factors (FGF) - Cytokines and Growth Factors
  7. FGF Receptors - Fibroblast Growth Factors (FGF)
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Fibroblast Growth Factor Receptor (FGFR) - Receptor Tyrosine Kinase Inhibitors

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