1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE

CAS N/A MFCD08705407

化学结构图

N/A
SMILES: O.OC(=O)C(F)(F)F.O=C1NC2C=CC=CC=2N1C1CCN(CC2C=CC(=CC=2)C2=NC3C=C4N=CNC4=CC=3N=C2C2C=CC=CC=2)CC1

化学属性

Mol. FormulaC34H29N7O · xC2HF3O2· yH2O
Mol. Weight551.64 (anhydrous free base basis)

别名和识别编码

Chemical NameAkt1/2 kinase inhibitor
Synonym 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one trifluoroacetate salt hydrate Akt Inhibitor VIII trifluoroacetate salt hydrate Akti-1/2 trifluoroacetate salt hydrate
MDL NumberMFCD08705407
PubChem Substance ID24891133
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分类

  • {SA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Merck, Protein Kinase B (Akt/PKB), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Merck, Protein Kinase B (Akt/PKB), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} A-AM, Approved Therapeutics/Drug Candidates,

相关文献及参考

  • Larson, B., et al., A Simple And Robust Automated Kinase Profiling Platform Using Luminescent ADP Accumulation Technology. Assay Drug Dev. Technol. 7 , 573-84, (2009) 摘要
  • Li, S., et al., From The Cover: Bifurcation Of Insulin Signaling Pathway In Rat Liver: MTORC1 Required For Stimulation Of Lipogenesis, But Not Inhibition Of Gluconeogenesis Proc. Natl. Acad. Sci. U. S. A. 107 , 3441-3446, (2010) 摘要
  • Li, S., et al., Bifurcation Of Insulin Signaling Pathway In Rat Liver: MTORC1 Required For Stimulation Of Lipogenesis, But Not Inhibition Of Gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A. 107 , 3441-6, (2010) 摘要
  • Desplat, V., et al., Synthesis And Evaluation Of The Antiproliferative Activity Of Novel Pyrrolo[1,2-a]quinoxaline Derivatives, Potential Inhibitors Of Akt Kinase. Part II. J. Enzyme Inhib. Med. Chem. 25 , 204-15, (2010) 摘要
  • Amanso, A.M., et al., Proteasome Inhibition Represses Unfolded Protein Response And Nox4, Sensitizing Vascular Cells To Endoplasmic Reticulum Stress-induced Death. PLoS ONE 6 , e14591, (2011) 摘要
  • Zhang, X. and T.A. Vik, Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase Leuk. Res. 21 , 849-856, (1997)
  • Zhao, Z., et al., Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors Bioorg. Med. Chem. Lett. 15 , 905-909, (2005)
  • Ajmani, S., et al., A comprehensive structure–activity analysis of protein kinase B-α (Akt1) inhibitors J. Mol. Graph. Model. 28 , 683-694, (2010)
  • Zhao, Z., et al., Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorg. Med. Chem. Lett. 15 , 905-909, (2005)
  • Barnett, S.F., et al, Identification and characterization of pleckstrin-h

安全信息

WGK Germany3

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Protein Kinase B (Akt/PKB) - Serine/Threonine Kinase Inhibitors

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