4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉

CAS 183322-18-1 MFCD09751265

化学结构图

183322-18-1
SMILES: COCCOC1=CC2C(Cl)=NC=NC=2C=C1OCCOC

化学属性

Mol. FormulaC14H17ClN2O4
Mol. Weight313
Melting Point99.0 to 104.0 deg-C

别名和识别编码

Chemical Name4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
CAS Number183322-18-1
Alfabeta NameCHLOROBISMETHOXYETHOXYQUINAZOLINE 4672()----,
MDL NumberMFCD09751265
Synonym 4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline 4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline PF-508367 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-Chloro-6,7-di(2-methoxyethoxy) CP-335963 PF-508367
Chemical Name Translation4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉
LabNetwork Molecule IDLN00171912
PubChem Substance ID329823700
Reaxys-RN8781189
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分类

  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Diversification Ready Pharma-Developed Compounds, Kinase/Phosphatase Biology, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学,

产品应用

  • CP-335963 is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.

相关文献及参考

  • Ban, H.S., et al., Allene as an alternative functional group for drug design: effect of C-C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase. ChemMedChem 3 , 1094-1103, (2008)
  • Bedi, P., et al.: Bioorg. Med. Chem. Lett., 14, 5211 (2004),
  • Lueth, A., and Loewe, W., A new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur. J. Med. Chem. 43 , 1478-1488, (2008)
  • Mosaad, S., et al.: J. Biol. Sci., 4, 504, (2004),
  • Zheng, Y., et al.: Chem. Biol. Drug Des., 76, 285 (2010),

安全信息

Warnings IRRITANT
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Signal word Danger
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Protein Kinases (PK) - Serine/Threonine Kinase Inhibitors

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