3-(4-((3-Phenoxybenzyl)Amino)Phenyl)Propanoic Acid 4-[[(3-苯氧苯基)甲基]氨基]苯基乙酸

CAS 885101-89-3 MFCD09753282

化学结构图

885101-89-3
SMILES: OC(=O)CCC1C=CC(=CC=1)NCC1C=C(C=CC=1)OC1C=CC=CC=1

化学属性

Mol. FormulaC22H21NO3
Mol. Weight347

别名和识别编码

Chemical Name3-(4-((3-Phenoxybenzyl)Amino)Phenyl)Propanoic Acid
Synonym 4-(3-Phenoxybenzylamino)phenylpropionic acid GW9508
MDL NumberMFCD09753282
Chemical Name Translation4-[[(3-苯氧苯基)甲基]氨基]苯基乙酸
PubChem Substance ID329799992
CAS Number885101-89-3
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, G, Lipids in Cell Signaling, Other Bioactive Lipids, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, Other Bioactive Lipids

相关文献及参考

  • [2]. Fujita T, et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol, 2011, 131(8), 1660-1667.
  • [3]. Zhao YF, et al. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J Endocrinol, 2008, 198(3), 533-540.
  • [4]. Suski M, et al. Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice. Pharmacol Rep. 2019 Aug;71(4):551-555.
  • [1]. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of
  • [1]. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P310
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Hazard Codes Xn,N
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R50/53
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Other Bioactive Lipids - Lipids in Cell Signaling
  1. Medical Research Areas
  2. GPCR & G Protein
  3. GPR40  (G蛋白偶联受体40)

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