PD-407824
CAS 622864-54-4 MFCD09753286
化学结构图
SMILES: OC1=CC2C3C4=C(C(=CC=3NC=2C=C1)C1C=CC=CC=1)C(=O)NC4=O
化学属性
| Mol. Formula | C20H12N2O3 |
|---|---|
| Mol. Weight | 328.32 |
别名和识别编码
| Chemical Name | PD-407824 |
|---|---|
| CAS Number | 622864-54-4 |
| Synonym | 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione PD 0407824 |
| MDL Number | MFCD09753286 |
| PubChem Substance ID | 329823703 |
| Chemical Name Translation |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Checkpoint Kinase (ChK), Fluorination Ready Pharma-Developed Compounds, Kinase/Phosphatase Biology, P-PH, Pfizer Compounds, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学,
产品应用
- PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments.
相关文献及参考
- Antunes, J., et al.: Eur. J Med. Chem., 43, 1632 (2008),
- Palmer, B.D., et al. J. Med. Chem. 49 , 4896, (2006)
- Pinheiro, J., et al.: Bioorg. Med. Chem., 16, 1683 (2008),
- Yi, P., et al.: Eur. J. Med. Chem., 43, 925 (2008),
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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