4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octan-8-Yl)-1-Phenylpropyl)Cyclohexane-1-Carboxamide 4,4-二氟-N-((S)-3-((1R,3R,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷-8-基)-1-苯基丙基)环己烷-1-酰胺

CAS 376348-65-1 MFCD09953791

化学结构图

376348-65-1
SMILES: CC1=NN=C(C(C)C)N1C1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)C1C=CC=CC=1

化学属性

Mol. FormulaC29H41F2N5O
Mol. Weight513.67

别名和识别编码

Chemical Name4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octan-8-Yl)-1-Phenylpropyl)Cyclohexane-1-Carboxamide
CAS Number376348-65-1
Synonym 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl-d6)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide UK 427857-d6
Chemical Name Translation4,4-二氟-N-((S)-3-((1R,3R,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷-8-基)-1-苯基丙基)环己烷-1-酰胺
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分类

  • Chiral Reagents
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Pfizer compounds

产品应用

  • Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.

相关文献及参考

  • [2]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802.
  • [3]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64.
  • [4]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.
  • Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003),
  • Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005),
  • Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),
  • [1]. Dor
  • [1]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. CCR  (趋化因子受体)

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