Canertinib dihydrochloride N-[4-[(3-氯-4-氟苯基)氨基]-7-(3-吗啉-4-基丙氧基)喹唑啉-6-基]-2-丙烯酰胺二盐酸盐

CAS 289499-45-2 MFCD09954112

化学结构图

289499-45-2
SMILES: Cl.Cl.C=CC(=O)NC1=CC2C(NC3C=C(Cl)C(F)=CC=3)=NC=NC=2C=C1OCCCN1CCOCC1

化学属性

Mol. FormulaC24H25ClFN5O3· 2HCl
Mol. Weight558.86

别名和识别编码

Chemical NameCanertinib dihydrochloride
Synonym CI-1033 Canertinib dihydrochloride Canertinib dihydrochloride N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride PD183805 N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride PD183805
MDL NumberMFCD09954112
CAS Number289499-45-2
PubChem Substance ID329775143
Chemical Name TranslationN-[4-[(3-氯-4-氟苯基)氨基]-7-(3-吗啉-4-基丙氧基)喹唑啉-6-基]-2-丙烯酰胺二盐酸盐
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index,
  • Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
  • {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors,
  • {SNA} Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
  • {SNA}

相关文献及参考

  • Bahrami, J., et al Gastroenterology , (2010)
  • Sonne-Hansen, K., et al Breast Cancer Res. Treat. , (2009)
  • Garland, LL., et al Clin. Cancer Res. 12 , 4274-4282, (2006)
  • Merck 14 ,1744

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUC6316110
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. CI-CY - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2) - Receptor Tyrosine Kinase Inhibitors

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