3-(2-Chloro-4-((3-(2,6-Dichlorophenyl)-5-Isopropylisoxazol-4-yl)Methoxy)Styryl)Benzoic Acid 3-(2-氯-4-((3-(2,6-二氯苯基)-5-异丙基异恶唑-4-基)甲氧基)苯乙烯基)苯甲酸
CAS 278779-30-9 MFCD09971006
化学结构图
SMILES: CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(C=Cc2cccc(C(=O)O)c2)c(Cl)c1
化学属性
| Mol. Formula | C28H22Cl3NO4 |
|---|---|
| Mol. Weight | 542.84 |
别名和识别编码
| Chemical Name | 3-(2-Chloro-4-((3-(2,6-Dichlorophenyl)-5-Isopropylisoxazol-4-yl)Methoxy)Styryl)Benzoic Acid |
|---|---|
| CAS Number | 278779-30-9 |
| Synonym | 3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole 3-[2-[2-Chloro-4-[[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic Acid GW 4064 GW-4064 GW4064 |
| MDL Number | MFCD09971006 |
| PubChem Substance ID | 9893571 |
| Chemical Name Translation | 3-(2-氯-4-((3-(2,6-二氯苯基)-5-异丙基异恶唑-4-基)甲氧基)苯乙烯基)苯甲酸 |
| InChI | InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+ |
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分类
- Pharmaceuticals
- {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, GlaxoSmithKline, Nuclear Translocation Regulators
- {SNA} Approved Therapeutics/Drug Candidates, Gene Regulation and Expression, GlaxoSmithKline, Nuclear Translocation Regulators, 生物活性小分子,
产品应用
- A novel nonsteroidal FXR nuclear receptor agonist.
相关文献及参考
- [2]. Ma Y, et al. Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and resistance. Pharm Res. 2013 May;30(5):1447-57.
- [3]. Liu Y, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest. 2003 Dec;112(11):1678-87.
- Carlton, V.E., et al.: Nat. Genet., 34, 91 (2003),
- Makishima, M., et al.: Science, 284, 1362 (1999),
- Wang, H., et al.: Mol. Cell, 3, 543 (1999),
- Zhang, Y., et al.: J. Biol. Chem., 276, 43018 (2001),
- [1]. Akwabi-Ameyaw A, et al.Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.
- [1]. Akwabi-Ameyaw A, et al.Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.
- [2]. Ma Y, et al. Synthetic FXR agonist GW4064 prevent
安全信息
GHS Symbol
Precautionary statements
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P305+P351+P338
- P330 Rinse mouth. 漱口
- P337+P313
- P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
WGK Germany3
Signal word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes
Xn
Risk Statements
- R36 Irritating to eyes 刺激眼睛
- R22 Harmful if swallowed 吞咽有害
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