1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea 1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲
CAS 228559-41-9 MFCD09971092
化学结构图
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
化学属性
| Mol. Formula | C24H18F3N3O4 |
|---|---|
| Mol. Weight | 469.41 |
| Appearance | White to off-white solid powder |
| Solubility | Soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name | 1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea |
|---|---|
| Synonym | 1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea 水合物 Ki 8751 Ki-8751 Ki8751 Ki8751; Ki-8751; Ki 8751 N-(2,4-difluorophenyl)-N'-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-fluorophenyl)urea |
| MDL Number | MFCD09971092 |
| Chemical Name Translation | 1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲 |
| PubChem Substance ID | 11317348 |
| InChI | InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) |
| LabNetwork Molecule ID | LN00334069 |
| Formula | C24H18F3N3O4 |
| IUPAC Name | 1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea |
| InChIKey | LFKQSJNCVRGFCC-UHFFFAOYSA-N |
| Canonical SMILES | O=C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1F)NC4=CC=C(F)C=C4F |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, Vascular Endothelial Growth Factor Receptor (VEGFR)
产品应用
- Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFR α and FGFR-2 (IC50 values range from 40 to 170 nM).
安全信息
GHS Symbol
Hazard statements
- H315 Causes skin irritation 会刺激皮肤
WGK Germany3
Signal word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage condition
0 – 4 C for short term (weeks to 1 month) or -20 C for long terms (months to years).
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