5-(5,6-Dimethoxy-1H-Benzimidazol-1-Yl)-3-{[2-(Trifluoromethyl)-Benzyl]Oxy}Thiophene-2-Carboxamide 5-(5,6-二甲氧基-1H-苯并咪唑-1-基)-3-{[2-(三氟甲基)-苄基]氧基}噻吩-2-甲酰胺

CAS 660868-91-7 MFCD09971143

化学结构图

660868-91-7
SMILES: COC1C=C2C(=CC=1OC)N=CN2C1=CC(OCC2=CC=CC=C2C(F)(F)F)=C(S1)C(N)=O

化学属性

Mol. FormulaC22H18F3N3O4S
Mol. Weight477.46

别名和识别编码

Chemical Name5-(5,6-Dimethoxy-1H-Benzimidazol-1-Yl)-3-{[2-(Trifluoromethyl)-Benzyl]Oxy}Thiophene-2-Carboxamide
Synonym 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide GW843682 GW843682
MDL NumberMFCD09971143
CAS Number660868-91-7
PubChem Substance ID329799898
Chemical Name Translation5-(5,6-二甲氧基-1H-苯并咪唑-1-基)-3-{[2-(三氟甲基)-苄基]氧基}噻吩-2-甲酰胺
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, GlaxoSmithKline, Kinase/Phosphatase Biology, Polo-like Kinases (PLK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
  • {SNA} Approved Therapeutics/Drug Can

相关文献及参考

  • Lansing, T.J., et al., In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol. Cancer Ther. 6 , 450-459, (2007) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Polo-like Kinases (PLK) - Serine/Threonine Kinase Inhibitors

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