Sodium (4-Chloro-3-Methylisoxazol-5-Yl)((2-(2-(6-Methylbenzo[D][1,3]Dioxol-5-Yl)Acetyl)Thiophen-3-Yl)Sulfonyl)Amide (4-氯-3-甲基异恶唑-5-基)((2-(2-(6-甲基苯并[d][1,3]二氧杂戊环-5-基)乙酰基)噻吩-3-基)磺酰基)胺钠盐

CAS 210421-74-2 MFCD11040990

化学结构图

210421-74-2
SMILES: Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)[N-]c1onc(C)c1Cl)OCO2.[Na+]

化学属性

Mol. FormulaC18H14ClN2NaO6S2
Mol. Weight476.89

别名和识别编码

Chemical NameSodium (4-Chloro-3-Methylisoxazol-5-Yl)((2-(2-(6-Methylbenzo[D][1,3]Dioxol-5-Yl)Acetyl)Thiophen-3-Yl)Sulfonyl)Amide
CAS Number210421-74-2
Synonym N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide
Chemical Name Translation(4-氯-3-甲基异恶唑-5-基)((2-(2-(6-甲基苯并[d][1,3]二氧杂戊环-5-基)乙酰基)噻吩-3-基)磺酰基)胺钠盐
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Selective endothelin A (ETA) receptor antagonist. Antihypertensive. Used in treatment of chronic heart failure.

相关文献及参考

  • [2]. Tilton RG, et al. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist. Pulm Pharmacol Ther. 2000;13(2):87-97.
  • [3]. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6.
  • Horn, E.M., et al.: Expert. Opin. Invest. Drugs, 13, 1483 (2004),
  • Tilton, R.G., et al.: Pulm. Pharmacol. Ther., 13, 87 (2000),
  • Wu, C., et al.: J. Med. Chem., 40, 1690 (1997),
  • [1]. Hartman JC, et al. Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and si
  • [1]. Hartman JC, et al. Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. Can J Physiol Pharmacol. 2010 Jun;88

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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