Org 27569
CAS 868273-06-7 MFCD11045300
化学结构图
SMILES: CCC1=C(NC2=CC=C(Cl)C=C21)C(=O)NCCC1C=CC(=CC=1)N1CCCCC1
化学属性
| Mol. Formula | C24H28ClN3O |
|---|---|
| Mol. Weight | 409.95 |
别名和识别编码
| Chemical Name | Org 27569 |
|---|---|
| Synonym | 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Org 27569 |
| MDL Number | MFCD11045300 |
| EC Number | 278-169-7 |
| PubChem Substance ID | 329818922 |
| Chemical Name Translation | |
| CAS Number | 868273-06-7 |
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分类
- {SNA} Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, O, Pharmacologicals
- {SNA} Cannabinoids, Neurobiology, Neuroscience, Pharmacologicals, 细胞信号转导和神经科学,
相关文献及参考
- [2]. Fay JF, et al. A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem. 2012 Jul 30.
- [3]. Gamage TF, et al. In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569. Behav Pharmacol. 2014 Apr;25(2):182-5.
- [4]. Price MR, et al. Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol. 2005 Nov;68(5):1484-95.
- [5]. Baillie GL, et al. CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol. 2013 Feb;83(2):322-38.
- [1]. Jing L, et al. Effects of the cannabinoid CB? receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking
- [1]. Jing L, et al. Effects of the cannabinoid CB? receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Drug Alcohol Depend. 2014 Oct 1;143:251-6.
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