N-Hydroxy-1-(4-Methoxybenzyl)-1H-Indole-6-Carboxamide N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺
CAS 950762-95-5 MFCD11114393
化学结构图
SMILES: COc1ccc(Cn2ccc3ccc(C(=O)NO)cc32)cc1
化学属性
| Mol. Formula | C17H16N2O3 |
|---|---|
| Mol. Weight | 296.32 |
| Appearance | White to gray solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-Hydroxy-1-(4-Methoxybenzyl)-1H-Indole-6-Carboxamide |
|---|---|
| CAS Number | 950762-95-5 |
| Synonym | 1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]- N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide PCI 34051 PCI34051; PCI 34051; PCI-34051 |
| MDL Number | MFCD11114393 |
| Chemical Name Translation | N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺 |
| Formula | C17H16N2O3 |
| IUPAC Name | N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide |
| InChIKey | AJRGHIGYPXNABY-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20) |
| Canonical SMILES | O=C(C1=CC2=C(C=C1)C=CN2CC3=CC=C(OC)C=C3)NO |
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分类
- Apoptosis
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies.
相关文献及参考
- Balasubramanian, S. et al.: Leukemia, 22, 1026 (2008); Pipalia, N.H. et al.: Proc. Nat. Acad. Sci. USA, 108, 5620 (2011);
安全信息
GHS Symbol
- P305+P351+P338
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
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