4-[4-(4-Fluorophenyl)-1-(3-Phenylpropyl)-5-(4-Pyridinyl)-1H-Imidazol-2-Yl]-3-Butyn-1-Ol 4-[4-(4-氟苯基)-1-(3-苯基丙基)-5-(4-吡啶基)-1H-咪唑-2-基] -3-丁炔-1-醇
CAS 215303-72-3 MFCD11840606
化学结构图
SMILES: OCCC#Cc1nc(-c2ccc(F)cc2)c(-c2ccncc2)n1CCCc1ccccc1
化学属性
| Mol. Formula | C27H24FN3O |
|---|---|
| Mol. Weight | 425.49736 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 4-[4-(4-Fluorophenyl)-1-(3-Phenylpropyl)-5-(4-Pyridinyl)-1H-Imidazol-2-Yl]-3-Butyn-1-Ol |
|---|---|
| CAS Number | 215303-72-3 |
| Synonym | 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol RWJ67657; RWJ-67657; RWJ 67657 |
| Chemical Name Translation | 4-[4-(4-氟苯基)-1-(3-苯基丙基)-5-(4-吡啶基)-1H-咪唑-2-基] -3-丁炔-1-醇 |
| Formula | C27H24FN3O |
| IUPAC Name | 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol |
| InChIKey | QSUSKMBNZQHHPA-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2 |
| Canonical SMILES | OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4 |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Protein Kinase Inhibitors and Activators
产品应用
- RWJ-67657 is a potent p38 MAPK inhibitor, which inhibited the release of TNF-alpha by lipopolysaccharide (a monocyte stimulus)-treated human peripheral blood mononuclear cells with an IC(50) of 3 nM, as well as the release of TNF-alpha from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin B (a T cell stimulus), with an IC(50) value of 13 nM. This compound was approximately 10-fold more potent than the literature standard p38 kinase inhibitor SB 203580 in all p38 dependent in vitro systems tested.
相关文献及参考
- Fijen, J. et al.: Clin. Exp. Immunol., 124, 16 (2001); Westra, J. et al.: Int. Immunopharmacol., 5, 1259 (2005); Westra, J. et al.: Ann. Rheum. Dis., 63, 1453 (2004);
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