BICYCLO[2.2.2]OCTANE-1-ACETIC ACID, 4-[4-(4-AMINO-7,7-DIMETHYL-7H-PYRIMIDO[4,5-B][1,4]OXAZIN-6-YL)PHENYL]-

CAS 942999-61-3 MFCD11977738

化学结构图

942999-61-3
SMILES: CC1(C)OC2=NC=NC(N)=C2N=C1C1C=CC(=CC=1)[C@@]12CC[C@@](CC(O)=O)(CC1)CC2 |&1:19,22|

化学属性

Mol. FormulaC24H28N4O3
Mol. Weight420.51

别名和识别编码

Chemical NameBICYCLO[2.2.2]OCTANE-1-ACETIC ACID, 4-[4-(4-AMINO-7,7-DIMETHYL-7H-PYRIMIDO[4,5-B][1,4]OXAZIN-6-YL)PHENYL]-
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相关文献及参考

  • [2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-1568.
  • [3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29.
  • [4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
  • [1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.
  • [1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.
  • [2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficaciou

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Acyltransferase  (酰基转移酶)

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