5-[2-[(2R, 6S)-2,6-Dimethyl-4-Morpholinyl]-4-(4-Morpholinyl) Pyridino[2,3-D] Pyrimidin-7-Yl]-2-Methoxyphenylcarbinol 5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-D]嘧啶-7-基]-2-甲氧基苯甲醇

CAS 938440-64-3 MFCD11977741

化学结构图

938440-64-3
SMILES: COc1ccc(-c2ccc3c(N4CCOCC4)nc(N4C[C@H](C)O[C@H](C)C4)nc3n2)cc1CO

化学属性

Mol. FormulaC25H31N5O4
Mol. Weight465.54474
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-[2-[(2R, 6S)-2,6-Dimethyl-4-Morpholinyl]-4-(4-Morpholinyl) Pyridino[2,3-D] Pyrimidin-7-Yl]-2-Methoxyphenylcarbinol
Synonym KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794. rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morp holinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
CAS Number938440-64-3
MDL NumberMFCD11977741
PubChem Substance ID329825382
Chemical Name Translation5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-D]嘧啶-7-基]-2-甲氧基苯甲醇
FormulaC25H31N5O4
IUPAC Name(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
InChIKeyRFSMUFRPPYDYRD-CALCHBBNSA-N
InChIInChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
Canonical SMILESOCC1=CC(C2=NC3=NC(N4C[C@@H](C)O[C@@H](C)C4)=NC(N5CCOCC5)=C3C=C2)=CC=C1OC
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, K, Kinase/Phosphatase Biology, Mammalian target of Rapamycin (mTOR), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Mammalian target of Rapamycin (mTOR), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

产品应用

  • KU-0063794 is a potent and selective mTOT inhibitor, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). Ku-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated.(Source: Biochem J. 2009 Jun 12;421(1):29-42)

安全信息

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
Precautionary statements
  • P301+P310
WGK Germany3
Signal word Danger
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Mammalian target of Rapamycin (mTOR) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. S6 Kinase

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