Raltegravir Potassium 4-((4-氟苄基)氨基甲酰基)-1-甲基-2-(2-(5-甲基-1,3,4-恶二唑-2-甲酰氨基)丙-2-基)-6-氧代-1,6-二氢嘧啶-5-醇钾盐
CAS 871038-72-1 MFCD12031642
化学结构图
SMILES: Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c([O-])c(=O)n2C)o1.[K+]
化学属性
| Mol. Formula | C20H20FKN6O5 |
|---|---|
| Mol. Weight | 483 |
别名和识别编码
| Chemical Name | Raltegravir Potassium |
|---|---|
| CAS Number | 871038-72-1 |
| Synonym | 0518, MK Isentress MK 0518 MK-0518 MK0518 N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide Potassium Salt Potassium, Raltegravir Raltegravir Potassium raltegravir |
| Chemical Name Translation | 4-((4-氟苄基)氨基甲酰基)-1-甲基-2-(2-(5-甲基-1,3,4-恶二唑-2-甲酰氨基)丙-2-基)-6-氧代-1,6-二氢嘧啶-5-醇钾盐 |
| LabNetwork Molecule ID | LN01311482 |
| PubChem Substance ID | 23668479 |
| InChI | InChI=1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11;/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30);/q;+1/p-1 |
| MDL Number |
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分类
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.
相关文献及参考
- [2]. Hicks C, et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9
- [3]. Moss DM, et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6
- [4]. Hare S, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72.
- [5]. Lewis, M.G., et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010. 7: p. 21.
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- [1]. Hare, S., et al., Molecular mechanisms of retroviral integra
- [1]. Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62.
安全信息
- H318 Causes serious eye damage 严重伤害眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P304+P340
- P305+P351+P338
- P308+P313
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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