2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol 2-(4-氨基-1-异丙基-1H-吡唑并[3,4-d]嘧啶-3-基)-1H-吲哚-5-醇
CAS 1092351-67-1 MFCD12196869
化学结构图
SMILES: CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21
化学属性
| Mol. Formula | C16H16N6O |
|---|---|
| Mol. Weight | 308 |
| Density | 1.557 |
| Boiling Point | 642.045 |
| Appearance | Solid powder |
| Solubility | soluble in DMSO |
别名和识别编码
| Chemical Name | 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol |
|---|---|
| Synonym | 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol PP242 PP242; PP 242; PP-242; Torkinib. |
| Chemical Name Translation | 2-(4-氨基-1-异丙基-1H-吡唑并[3,4-d]嘧啶-3-基)-1H-吲哚-5-醇 |
| LabNetwork Molecule ID | LN01319331 |
| PubChem Substance ID | 135565635 |
| InChI | InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) |
| Formula | C16H16N6O |
| IUPAC Name | 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol |
| InChIKey | MFAQYJIYDMLAIM-UHFFFAOYSA-N |
| Canonical SMILES | OC1=CC2=C(NC(C3=NN(C(C)C)C4=NC=NC(N)=C43)=C2)C=C1 |
| MDL Number | MFCD12196869 |
| CAS Number | 1092351-67-1 |
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产品应用
- Torkinib, also known as PP242 is a selective mTOR inhibitor with IC50 of 8 nM. PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway. PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
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