Pomalidomide 泊马度胺

CAS 19171-19-8 MFCD12756407

化学结构图

19171-19-8
SMILES: Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

化学属性

Mol. Weight273
Mol. FormulaC13H11N3O4
Melting Point315.5-317.5
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Synonym CC4047; CC 4047; CC-4047; Pomalidomide. Brand name: Pomalyst.
Chemical NamePomalidomide
MDL NumberMFCD12756407
Chemical Name Translation泊马度胺
Reaxys-RN8340987
CAS Number19171-19-8
Merck Number135
InChIKeyUVSMNLNDYGZFPF-UHFFFAOYSA-N
PubChem Substance ID253660183
Beilstein Registry Number8340987
FormulaC13H11N3O4
IUPAC Name4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIInChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
Canonical SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N)=O
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分类

  • {SNA} Angiogenesis Regulators, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix
  • {SNA} Angiogenesis Regulators, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, 细胞生物学
  • {SNA} Angiogenesis Regulators, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, PI-PZ, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Pomalidomide, also known as CC4047, is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). Pomalidomide was approved on February 8, 2013 as a treatment for relapsed and refractory multiple myeloma.

安全信息

WGK Germany3
RTECSNR3397905
GHS Symbol
Signal word
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
Storage condition 0-10 0-10°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Extracellular Matrix - Cytoskeleton and Extracellular Matrix
  6. Angiogenesis Regulators - Extracellular Matrix
  1. Medical Research Areas
  2. Apoptosis
  3. TNF-alpha

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