4-((((2R,3S,4R,5R)-5-(6-Amino-8-((3,4-Dichlorobenzyl)Amino)-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)Benzonitrile 4-((((2R,3S,4R,5R)-5-(6-氨基-8-(3,4-二氯苄基)氨基)-9H-嘌呤-9-基)-3,4-二羟四氢呋喃-2-基)甲氧基)甲基)苯甲腈

CAS 1134156-31-2 MFCD18086892

化学结构图

1134156-31-2
SMILES: NC1=NC=NC2=C1N=C(NCC1C=C(Cl)C(Cl)=CC=1)N2[C@@H]1O[C@H](COCC2C=CC(=CC=2)C#N)[C@@H](O)[C@H]1O |&1:20,22,34,36|

化学属性

Mol. Weight556.40
Mol. FormulaC25H23Cl2N7O4

别名和识别编码

Synonym 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine VER-155008
Chemical Name4-((((2R,3S,4R,5R)-5-(6-Amino-8-((3,4-Dichlorobenzyl)Amino)-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)Benzonitrile
MDL NumberMFCD18086892
Chemical Name Translation4-((((2R,3S,4R,5R)-5-(6-氨基-8-(3,4-二氯苄基)氨基)-9H-嘌呤-9-基)-3,4-二羟四氢呋喃-2-基)甲氧基)甲基)苯甲腈
PubChem Substance ID329825279
CAS Number1134156-31-2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Heat Shock and Related Proteins, V, 一氧化氮和细胞应激, 伴侣蛋白和热休克蛋白, 生物活性小分子, 细胞信号转导和神经科学, 细胞应激, 细胞生物学
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Cha

相关文献及参考

  • [2]. Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.
  • [3]. Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.
  • [1]. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.
  • [1]. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.
  • [2]. Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.
  • [3].

安全信息

WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Cell Stress - Nitric Oxide and Cell Stress
  6. Chaperonins and Heat Shock Proteins - Cell Stress
  7. Heat Shock and Related Proteins - Chaperonins and Heat Shock Proteins
  1. Medical Research Areas
  2. Metabolism
  3. HSP  (热休克蛋白)

相关产品推荐