2-((4-(5-Ethylpyrimidin-4-Yl)Piperazin-1-Yl)Methyl)-6-(Trifluoromethyl)-1H-Benzo[D]Imidazole 2-((4-(5-乙基嘧啶-4-基)哌嗪-1-基)甲基)-6-(三氟甲基)-1H-苯并[d]咪唑

CAS 1255517-76-0 MFCD18086922

化学结构图

1255517-76-0
SMILES: CCc1cncnc1N1CCN(Cc2nc3cc(C(F)(F)F)ccc3[nH]2)CC1

化学属性

Mol. Weight390.40545
Mol. FormulaC19H21F3N6
Appearance solid powder
SolubilitySoluble to 50 mM in DMSO and to 50 mM in ethanol, not soluble in water

别名和识别编码

Synonym (2-(4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo(d)imidazole 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole PF-4708671 PF4708671; PF-4708671; PF 4708671.
MDL NumberMFCD18086922
CAS Number1255517-76-0
Chemical Name2-((4-(5-Ethylpyrimidin-4-Yl)Piperazin-1-Yl)Methyl)-6-(Trifluoromethyl)-1H-Benzo[D]Imidazole
Chemical Name Translation2-((4-(5-乙基嘧啶-4-基)哌嗪-1-基)甲基)-6-(三氟甲基)-1H-苯并[d]咪唑
PubChem Substance ID51371303
InChIInChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
FormulaC19H21F3N6
IUPAC Name2-((4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole
InChIKeyFBLPQCAQRNSVHB-UHFFFAOYSA-N
Canonical SMILESFC(C1=CC=C2NC(CN3CCN(C4=NC=NC=C4CC)CC3)=NC2=C1)(F)F
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Kinase/Phosphatase Biology, P-PH, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

产品应用

  • PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

安全信息

GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Protein Kinases (PK) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. S6 Kinase

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