JZL 195 4-(3-苯氧基苄基)哌嗪-1-甲酸对硝基苯酯
CAS 1210004-12-8 MFCD18382122
化学结构图
SMILES: [O-][N+](=O)C1C=CC(=CC=1)OC(=O)N1CCN(CC2C=C(C=CC=2)OC2C=CC=CC=2)CC1
化学属性
| Mol. Weight | 433.46 |
|---|---|
| Mol. Formula | C24H23N3O5 |
别名和识别编码
| Synonym | 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester |
|---|---|
| MDL Number | MFCD18382122 |
| CAS Number | 1210004-12-8 |
| Chemical Name | JZL 195 |
| PubChem Substance ID | 329825265 |
| Chemical Name Translation | 4-(3-苯氧基苄基)哌嗪-1-甲酸对硝基苯酯 |
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分类
- {SA} Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Fatty Acid Amide Hydrolase, Neurobiology, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pharmacologicals
- {SNA} Bioactive Small Molecule Alphabetical Index, Cannabinoids, Enzyme Inhibitors, Fatty Acid Amide Hydrolase, J, Neurobiology, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.
- Long, J.Z., et al,, Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J. Med. Chem. 4 , 1830-1842, (2010)
- Long, J.Z., et al., Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc. Natl. Acad. Sci. U. S. A. 48 , 20270-20275, (2010)
- [1]. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
- [1]. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
- [2]. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R50 Very toxic to aquatic organisms 对水生生物极毒
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