Bms-690514 BMS-690514

CAS 859853-30-8 MFCD18633295

化学结构图

859853-30-8
SMILES: COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1

化学属性

Mol. Weight368.43
Mol. FormulaC19H24N6O2
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameBMS-690514
CAS Number859853-30-8
Alfabeta NameAMINOMETHOXYPHENYLAMINOPYRROLOTRIAZINYLMETHYLPIPERIDINOL RRF3441432112453[[[[[]]]]](())------------,,,,
MDL NumberMFCD18633295
LabNetwork Molecule IDLN00169691
Chemical Name TranslationBMS-690514
PubChem Substance ID11349170
InChIInChI=1S/C19H24N6O2/c1-27-15-4-2-3-14(9-15)23-19-18-13(5-8-25(18)22-12-21-19)10-24-7-6-16(20)17(26)11-24/h2-5,8-9,12,16-17,26H,6-7,10-11,20H2,1H3,(H,21,22,23)/t16-,17-/m1/s1
Synonym (14C)BMS-690514 (3R,4R)-4-amino-1-((4-((3-methoxyphenyl)amino)pyrrolo(2,1-f)(1,2,4)triazin-5-yl)methyl)-3-piperidinol BMS-690514 BMS690514; BMS 690514; BMS-690514.
FormulaC19H24N6O2
IUPAC Name(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
InChIKeyCSGQVNMSRKWUSH-IAGOWNOFSA-N
Canonical SMILESO[C@@H]1CN(CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2)CC[C@H]1N
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产品应用

  • BMS-690514 is a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3. BMS-690514 is currently under investigation as an oral agent for the treatment of solid tumors. In vitro and in vivo studies were conducted to characterize the pharmacokinetics and metabolism. Through integration of in vitro and in vivo pharmacokinetic data and antitumor efficacy in nude mice, human pharmacokinetics and efficacious doses were projected for BMS-690514. The oral bioavailability of BMS-690514 was 78% in mice, approximately 100% in rats, 8% in monkeys, and 29% in dogs. The low oral bioavailability in monkeys could be attributed to high systemic clearance in that species, which was also consistent with predicted clearance using in vitro data from monkey liver microsomes. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation

安全信息

Warnings IRRITANT
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. EGFR
  1. Medical Research Areas
  2. Angiogenesis
  3. VEGFR
  1. Medical Research Areas
  2. GPCR & G Protein
  3. EGFR

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