2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid 2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸

CAS 56396-35-1 MFCD19443867

化学结构图

56396-35-1
SMILES: N#C/C(=C\C1=CN(C2C=CC=CC1=2)C1C=CC=CC=1)/C(O)=O

化学属性

Mol. Weight288.30
Mol. FormulaC18H12N2O2

别名和识别编码

Synonym 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid PF-1005023 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid PF-1005023
MDL NumberMFCD19443867
CAS Number56396-35-1
Chemical Name2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Chemical Name Translation2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸
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分类

  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds
  • Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds
  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds, U, 生物活性小分子,

相关文献及参考

  • [2]. Wiemer EA, et al. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem J. 1995 Dec 1;312 ( Pt 2):479-84.
  • [3]. Hinoi E, et al. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35. Epub 2006 Jun 9.
  • [4]. Patterson JN, et al. Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated secretion. J Biol Chem. 2014 May 9;289(19):13335-46.
  • [5]. Zhong Y, et al. Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro. Oncotarget. 2015 Nov 10;6(35):37758-69.
  • Butcher, L., et al., Metabolism of pyruvate by the early human embryo. Biol. Reprod. 58 , 1054-1056, (1998)
  • Nakamichi, N., et al., Protection by exogenous pyruvate thro

安全信息

Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Mitochondrial Proteins, Antibodies, and Transport Inhibitors - Apoptosis and Cell Cycle
  6. Mitochondrial Transport Inhibitors - Mitochondrial Proteins, Antibodies, and Transport Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)

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