5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione 5-[(2,2-二氟-1,3-苯并二恶茂-5-基)亚甲基]噻唑烷-2,4-二酮

CAS 648449-76-7 MFCD09265247

化学结构图

648449-76-7
SMILES: O=C1NC(=O)/C(=C/c2ccc3c(c2)OC(F)(F)O3)S1

化学属性

Mol. FormulaC11H5F2NO4S
Mol. Weight285.22
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione
Chemical Name Translation5-[(2,2-二氟-1,3-苯并二恶茂-5-基)亚甲基]噻唑烷-2,4-二酮
FormulaC11H5F2NO4S
Synonym AS604850; AS 604850; AS-604850.
IUPAC Name(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
InChIKeySRLVNYDXMUGOFI-YWEYNIOJSA-N
InChIInChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
Canonical SMILESO=C(NC/1=O)SC1=C/C2=CC=C(OC(F)(F)O3)C3=C2
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产品应用

  • AS-604850 is a selective PI3Kγ inhibitor, which significantly reduced the number of infiltrated leukocytes in the CNS and ameliorated the clinical symptoms of EAE mice. Treatment with this PI3Kγ inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3Kγ contributes to development of autoimmune CNS inflammation and that PI3Kγ blockade may provide a great potential for treating patients with MS.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. PI3K

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