3-(Oxiran-2-Yl)-7-Oxabicyclo[4.1.0]Heptane 二氧化乙烯基环己烯

CAS 106-87-6 MFCD00022354

化学结构图

106-87-6
SMILES: C1CC2OC2CC1C1CO1

化学属性

Mol. FormulaC8H12O2
Mol. Weight140.18
Refractive indexn20/D 1.477(lit.)
Boiling Point230-232 °C at 760 mmHg
Density1.094 g/mL at 25 °C(lit.)
Solubility溶于水。
Flash Point107.22°C
Melting Point-55 °C

别名和识别编码

Chemical Name3-(Oxiran-2-Yl)-7-Oxabicyclo[4.1.0]Heptane
MDL NumberMFCD00022354
CAS Number106-87-6
Synonym 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0
PubChem Substance ID7833
EC Number203-437-7
Beilstein Registry Number106071
Chemical Name Translation二氧化乙烯基环己烯
Wiswesser Line NotationT36 BOTJ A- BT3OTJ
LabNetwork Molecule IDLN00238998
InChIInChI=1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2
Canonical SMILESC1(C2OC2)CCC3C(O3)C1
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分类

  • {SNA} Analytical Reagents, Analytical/Chromatography, Embedding Media, Embedding and Mounting Media, Microscopy Reagents
  • {SNA} Embedding Media, Embedding and Mounting Media, Microscopy Reagents, 分析/色谱, 分析试剂

产品应用

  • 乙烯基环己烯二氧化物（VCD）作为一种卵巢毒素可用于研究其毒性。 VCD是用来研究其对卵巢滤泡及上皮细胞分化的毒性影响机制。

相关文献及参考

  • Beilstein: 19,IV,161

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSRN8640000
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Hazard Codes T
Risk Statements
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R68/20/21/22
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Packing GroupIII
Hazard Class6.1(b)
UN Number UN 2810 6.1/PG 3 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31500 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 gm/kg/74W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   24,305,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5000 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   RARSAM Radiation Research, Supplement.  (New York, NY)  No.1-7, 1959-67.
   Discontinued.  Volume(issue)/page/year: 3,193,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 620 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 9/19/1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCCUR* Shell Chemical Company.  Unpublished Report.  (2401 Crow Canyon Rd.,
   San Romon, CA 94583)  Volume(issue)/page/year: -,9,1961

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3216 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCCUR* Shell Chemical Company.  Unpublished Report.  (2401 Crow Canyon Rd.,
   San Romon, CA 94583)  Volume(issue)/page/year: -,9,1961

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3730 pg/kg
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

{

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mmol/L
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 56,1803,1980

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 125 mg/kg
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,235,1951

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,367,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 1 mmol/L
REFERENCE :

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mmol/L
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 56,1803,1980

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4800 mg/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 12,435,1992

Storage condition

其他信息

  • 上游原料:甲苯 --> 碳酸钠 --> 三氯甲烷 --> 乙腈 --> 环己烷 --> 1,3-丁二烯 --> 过氧乙酸 --> 氧化亚铜 --> 十二烷基苯磺酸 --> 正丁烷 --> 过氧化氢苯甲酰 --> 1,10-菲罗啉(一水合物) --> 靛蓝 --> 无水高氯酸铁
  • 急性毒性:口服- 大鼠 LD50: 2130 毫克/ 公斤; 吸入-大鼠 LC50: 800 ppm/4小时
  • 类别:有毒物质
  • 毒性分级:中毒
  • 灭火剂:水, 二氧化碳, 泡沫, 干粉
  • 爆炸物危险特性:聚合放热, 密闭容器可爆炸
  • 用途一:用于电子显微镜
  • MSDS 信息:106-87-6.msds
  • 职业标准:TWA 60 毫克/立方米; STEL 90 毫克/立方米
  • 外观性质:透明水溶性液体, 有微弱烯烃气味。
  • 可燃性危险特性:可燃;燃烧放出刺激烟雾
  • 储运特性:库房低温, 通风, 干燥
  • Sigma Aldrich:106-87-6(sigmaaldrich)
  • MOL 文件:106-87-6.mol
  • 刺激数据:皮肤- 兔 500 毫克 重度

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Microscopy Reagents - Analytical Reagents
  4. Embedding and Mounting Media - Microscopy Reagents
  5. Embedding Media - Embedding and Mounting Media

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