1-(2-Hydroxyethyl)Ethyleneimine 1-(2-羟乙基)氮丙啶

CAS 1072-52-2 MFCD00005119

化学结构图

1072-52-2
SMILES: OCCN1CC1

化学属性

Mol. FormulaC4H9NO
Mol. Weight87.12
Refractive index1.4540 to 1.4590
Autoignition Point635 °F
Vapor Density3 (vs air)
Boiling Point167-168°C at 760 mmHg
Density1.088
Flash Point85°C(lit.)
TSCAYes

别名和识别编码

Chemical Name1-(2-Hydroxyethyl)Ethyleneimine
Synonym 2-(1-Aziridinyl)ethanol {LY} 2-(1-Aziridinyl)ethanol {} {LY} 2-(1-Aziridinyl)ethanol {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(1-Aziridinyl)ethanol {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00005119
CAS Number1072-52-2
PubChem Substance ID87570954
EC Number214-009-4
Reaxys-RN102514
Chemical Name Translation1-(2-羟乙基)氮丙啶
Wiswesser Line NotationT3NTJ A2Q
Beilstein Registry Number0102514
LabNetwork Molecule IDLN00221528
InChIInChI=1S/C4H9NO/c6-4-3-5-1-2-5/h6H,1-4H2
Canonical SMILESOCCN1CC1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 3ring; alcohol; 1fragment

相关文献及参考

  • Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSCM7000000
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P370+P378
  • P304+P340
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P305+P351+P338
  • P304+P340+P310
  • P403+P235
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P311
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P303+P361+P353+P310+P363
  • P301+P310+P330
Signal word Danger
Packing GroupII
UN Number UN2927 2922
Risk Statements
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
Hazard Codes T
Hazard Class8/6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg/75W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   46,143,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 31,60,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03613

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >850 ppm/8H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 11/17/1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 71 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 11/17/1964

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 50 ppm
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,325,1985

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,3270,1984

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 100 ppm
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,325,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,3270,1984

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 储运特性:通风低温干燥; 与库房食品原料分开存放
  • {Chemicalbo
  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
  • Sigma Aldrich:1072-52-2(sigmaaldrich)
  • 毒性分级:高毒
  • Alfa Aesar:1-丫啶乙醇,97% 1-Aziridineethanol, 97%(1072-52-2)
  • 图谱信息:1-羟乙基氮丙啶
  • 图谱信息:1-羟乙基氮丙啶 (1072-52-2)红外图谱(IR1) 1-羟乙基氮丙啶 (1072-52-2)核磁图( 1 HNMR) 1-羟乙基氮丙啶 (1072-52-2)质谱(MS) 1-羟乙基氮丙啶
  • 刺激数据:皮肤-兔子 545 毫克 中度; 眼睛-兔子 1090 毫克 重度
  • 急性毒性:口服-大鼠 LD50: 74 毫克/公斤; 静脉-小鼠 LD50: 56 毫克/公斤
  • MOL 文件:1072-52-2.mol
  • 上游原料:氢氧化钠 --> 苯 --> 曙光红(四溴荧光素) --> 氮丙啶
  • TCI Shanghai:1-羟乙基氮丙啶 1-(2-Hydroxyethyl)ethyleneimine,>;97.0%(GC)(T)(1072-52-2)

系列性分类


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